Personalized diagnosis in suspected myocardial infarction. Clinical research in cardiology : official journal of the German Cardiac Society,

Neumann, J. T., Twerenbold, R., Ojeda, F., Aldous, S. J., Allen, B. R., Apple, F. S., Babel, H., Christenson, R. H., Cullen, L., Di Carluccio, E., Doudesis, D., Ekelund, U., Giannitsis, E., Greenslade, J., Inoue, K., Jernberg, T., Kavsak, P., Keller, T., Lee, K. K., Lindahl, B., … ARTEMIS study group, Hall, E., Keijzers, G. (2023). Personalized diagnosis in suspected myocardial infarction. Clinical research in cardiology : official journal of the German Cardiac Society, 10.1007/s00392-023-02206-3. Advance online publication.

Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis.

Macdonald, S., Bosio, E., Keijzers, G., Burrows, S., Hibbs, M., O'Donoghue, H., Taylor, D., Mukherjee, A., Kinner, F., Smart, L., Ascencio-Lane, J., Litton, E., Fraser, J., Shapiro, N., Arendts, G., The REFRESH Trial Investigators and  Fatovich, D. (2023). Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis. Intensive Care Med Exp, 11(1), 21. 

Computed tomography brain scan utilization in patients with headache presenting to emergency departments: a multinational study. European Journal of Emergency Medicine

Chu, K., Kelly, A.M., Keijzers, G., Kinnear, F., Kuan, W.S., Graham, C., Laribi, S., Roberts, T., Karamercan, M., Cardozo-Ocampo, A. and Kamona, S., 2023. Computed tomography brain scan utilization in patients with headache presenting to emergency departments: a multinational study. European Journal of Emergency Medicine, pp.10-1097. 

Impact of time of intensive care unit transfer and outcomes in patients with septic shock: An observational study. Emergency Medicine Australasia.

Buhariwalla, K., Keijzers, G., Macdonald, S., Finnis, M., Peake, S., Gillett, M., Delaney, A. and ARISE Investigators, 2023. Impact of time of intensive care unit transfer and outcomes in patients with septic shock: An observational study. Emergency Medicine Australasia.

Emergency department presentations during the COVID‐19 pandemic in Queensland (to June 2021): interrupted time series analysis. Medical journal of Australia.

Sweeny, A.L., Keijzers, G., Marshall, A., Hall, E.J., Ranse, J., Zhang, P., Grant, G., Huang, Y.L., Palipana, D., Teng, Y.D. and Gerhardy, B., 2022. Emergency department presentations during the COVID‐19 pandemic in Queensland (to June 2021): interrupted time series analysis. Medical journal of Australia.

Single High-Sensitivity Point of Care Whole Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk. Circulation.

Apple, F.S., Smith, S.W., Greenslade, J.H., Sandoval, Y., Parsonage, W., Ranasinghe, I., Gaikwad, N.J., Schulz, K., Stephensen, L., Schmidt, C.W. and Okeson, B., 2022. Single High-Sensitivity Point of Care Whole Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk. Circulation. 

Does distance to hospital affect emergency department presentations and hospital length of stay among chronic obstructive pulmonary disease patients?. Internal Medicine Journal

Rana, R., Gow, J., Moloney, C., King, A., Keijzers, G., Beccaria, G. and Mullens, A., 2022. Does distance to hospital affect emergency department presentations and hospital length of stay among chronic obstructive pulmonary disease patients?. Internal Medicine Journal, 52(3), pp.403-410. https://doi.org/10.1111/imj.15014
 

Pregabalin vs placebo to prevent chronic pain after whiplash injury in at-risk individuals: results of a feasibility study for a large randomised controlled trial. Pain,

Nikles, J., Keijzers, G., Mitchell, G., Farrell, S.F., Perez, S., Schug, S., Ware, R.S., McLean, S.A., Connelly, L.B. and Sterling, M., 2022. Pregabalin vs placebo to prevent chronic pain after whiplash injury in at-risk individuals: results of a feasibility study for a large randomised controlled trial. Pain, 163(2), pp.e274-e284. doi: 10.1097/j.pain.0000000000002362

FEISTY II: Blood clot treatments for patients with severe bleeding compared in new phase of clinical trial

The Fibrinogen Early In Severe Trauma Study II, known as FEISTY II has begun at Gold Coast Health.

FEISTY II represents a vital step forward in the quest for improved trauma care and builds on the success of FEISTY I. The study has garnered international attention for its efforts to optimise use of blood products in severely bleeding trauma patients.

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Vasopressor Infusion via Peripheral vs Central Access in emergency department patients with shock – The VIPCA RCT

Quick facts

Principal investigator:

Dr Thomas Holland

Team members:

Professor Gerben Keijzers, Dr Mahesh Ramana, Dr Yogesh Apte and Ms Stacey Watts, Professor Robert Ware, A/Professor Joshua Byrnes, Dr Alison Craswell, A/Professor Frances Lin, A/Professor Chris Anstey and Dr Alexis Tabah

Project commenced:
2022

Shock is an umbrella description for poor blood supply to vital organs and can lead to multi-organ failure and death. Emergency department (ED) patients with shock are amongst the sickest, with 1/3 being admitted to an intensive care unit (ICU). Low blood pressure, a key feature of shock which causes the poor blood supply to vital organs, can be treated with medications called vasopressors. Vasopressors traditionally have been given through a so-called 'central line'. Central lines are invasive to insert and require skill, and the actual insertion can lead to complications. More evidence has emerged that so-called peripheral lines (aka 'drip') are safe for vasopressor infusion. Randomised controlled trials (RCT) to compare the two strategies will provide high quality data to inform clinicians as to which approach is best for patients, staff and the healthcare budget. We propose a feasibility RCT to test processes and inform a large phase-III RCT to definitively answer this question. We expect that the impacts of this RCT will include: *Potentially improved patient outcomes from avoiding risks of central lines * Improved patient experience from avoiding having central line insertion * Broad applicability to low-resource settings such as rural/regional/remote areas and low-income countries *Cost savings for healthcare services through reduced use of central lines

Grants Awarded

Emergency Medicine Foundation
$38,766
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