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Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis, a multicentre observational study (ARISE FLUIDS observational study): Rationale, methods and analysis plan.

Keijzers, G., Macdonald, S.P., Udy, A.A., Arendts, G., Bailey, M., Bellomo, R., Blecher, G.E., Burcham, J., Delaney, A., Coggins, A.R. and Fatovich, D.M., 2019. The Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis, a multicentre observational study (ARISE FLUIDS observational study): Rationale, methods and analysis plan. Emergency Medicine Australasia, 31(1), pp.90-96.

Australasian Resuscitation In Sepsis Evaluation: Fluid or Vasopressors in Emergency Department Sepsis (ARISE:Fluids) Trial.

Quick facts

Principal investigator:
Prof Gerben Keijzers
Team members:
Peake S, Mcdonald S, Delaney A, Keijzers G
Project commenced:
2020

Findings from a Gold Coast Health driven investigation into the use of intravenous fluids in sepsis management in emergency patients will be used as the foundation for a larger, $2.33M randomised controlled trial. 

Sepsis, although not very common, is a serious condition where infection leads to organ dysfunction and possibly death. 

The planned ARISE: Fluids study will explore liberal versus restricted fluid management in patients with septic shock after a large study led by principal investigator Professor Gerben Keijzers showed that there was large variation in how much fluid patients were given.

Grants Awarded

The Medical Research Future Fund (MRFF)
$2,335,540


Gold Coast sepsis research leads to up-sized fluid treatment study

Findings from a Gold Coast Health driven investigation into the use of intravenous fluids in sepsis management in emergency patients will be used as the foundation for a larger, $2.33M randomised controlled trial.


Queen's Birthday honour for emergency care researcher

Professor of Emergency Care Dr Julia Crilly, has been awarded an Order of Australia Medal for her service to emergency care nursing. 

Prof Crilly OAM leads and supports research in Gold Coast Health’s emergency department, and has a special research interest in the improvement of emergency care for vulnerable population groups.

Dr Crilly has independently and jointly been involved in gaining more than $6 million in grants to fund research projects that enable clinicians and students to be mentored. 


Nasal High Flow Therapy Treatment for Children with Acute Hypoxemic Respiratory Failure - a PARIS trial (PARIS 2)

Quick facts

Principal investigator:
Dr Shane George
Team members:
A/Prof Susan Moloney, Mr Riku Haataja, Dr Donna Franklin
Project commenced:
2017

Acute hypoxic respiratory distress (AHRF) such as pneumonia, caused by an infection imposes the greatest health care burden on non-elective hospital admissions. The early use of non-invasive respiratory to facilitate respiratory support may avoid progression of the disease.

Nasal High Flow therapy (NHF) therapy has emerged as a new method to provide a form of positive pressure support with
titratable oxygen fraction. There is a lack of high-grade evidence on the use of NHF therapy in children with AHRF.

Eight in 1000 infants less than 12 months of age need hospital admission due to acute respiratory infection and represents the greatest number of non-elective intensive care admissions in the USA with a cost over U$ 1.7 billion per year.

This study at Gold Coast University Hospital aims to compare NHF therapy to standard subnasal oxygentherapy, in children 0-16 yrs of age with AHRF presenting to hospital. The primary outcome is treatment failure of NHF therapy or standard subnasal oxygen therapy.

Gold Coast University Hospital will be the first hospital in 2017, following the pilot trial at LCCH in 2016, to enrol patients on this much needed study.

The NHMRC awards Dr Donna Franklin (new member of our GCH ED research team) an Early Careers Researcher fellowship valued at $645,000 to continue the work on early respiratory support in children, following on from the PARIS studies GCH ED research has been involved in since 2014.
 

Grants Awarded

NHMRC
$2,600,000

NHMRC
$645,000


Medical and nursing staff experiences of working during COVID-19: An Emergency Department and Intensive Care Unit study to inform preparedness and response

Quick facts

Principal investigator:
Dr Jamie Ranse, Mercedes Carrington
Team members:
Dr Jamie Ranse, Mercedes Carrington, Prof Julia Crilly, Dr Gerben Keijzers
Project commenced:
2020

Medical and nursing staff experiences of working during COVID-19: An Emergency Department and Intensive Care Unit study to inform preparedness and response.

Grants Awarded

SERTA Small Research Project Grant
$10,000


The Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis, a multicentre observational study (ARISE FLUIDS observational study): Rationale, methods and analysis plan

Keijzers, Gerben, Stephen PJ Macdonald, Andrew A. Udy, Glenn Arendts, Michael Bailey, May Katya, Rinaldo Bellomo, Gabriel E. Blecher et al. "The Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis, a multicentre observational study (ARISE FLUIDS observational study): Rationale, methods and analysis plan." Emergency Medicine Australasia 31, no. 1 (2019): 90-96.

Amy Sweeny is an epidemiologist and registered nurse with two decades of experience in hospital-based research. She is a lecturer at Griffith University and an Honorary Adjunct Assistant Professor at Bond University. She currently works as the research development manager for the Emergency Department Collaborative Research Group and is responsible for tracking research projects and their outputs and supervising students from both Bond and Griffith Universities. She often assists with study development and statistical analysis across the research pillars.
She is an investigator on research projects related to improving intravenous cannulation practices in adults and children, the care of vulnerable populations, and disaster preparedness.
She is interested in communicable diseases, cardiovascular diseases, developing emergency medicine and the application of machine learning to improve healthcare.

Awards/Achievements
- Queensland Health The Improvers Peoples Choice Award (2019)
- Queensland Health’s Artificial Intelligence Hub Datathon winner (2020)

Connect with Ms Sweeny : Search gate

Nasal High Flow Therapy for Infants with Bronchiolitis – Translating new knowledge into practice

Quick facts

Principal investigator:
Dr Shane George
Team members:
Dr Susan Moloney, Mr Nathan Goddard
Project commenced:
2019

Bronchiolitis, a lower respiratory tract infection which causes inflammation of the small airways in infants, imposes the largest health care burden on hospital admissions worldwide, with up to 15 % of admissions to intensive care.

Nasal High Flow (NHF) therapy has emerged as a new method to support the breathing of these infants avoiding intensive care admission. We have shown in a previous large study that NHF therapy can be used in regional and metropolitan hospitals and reduces the need to transfer infants to a specialised children’s hospital. This new project entails working with six of the regional Queensland hospitals from the previous study to explore the optimal way to translate the new knowledge into practice.

We will compare three sites provided with structured educational support to three sites with no additional educational support. We suspect that the centres receiving the additional support will retain the knowledge and skill level to maintain and sustain optimal improved outcomes and have better uptake and adherence to evidence based NHF therapy guidelines for admitted infants with bronchiolitis.

Grants Awarded

CHF AusHSI Implementation Grant
$80,000


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