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Fibrinogen Early in Children with Severe Traumatic Haemorrhage - FEISTY Junior

Quick facts

Principal investigator:
Dr Shane George
Team members:
Dr Christa Bell, Dr James Winearls, Ms Elizabeth Wake
Project commenced:

Traumatic injuries in children are a leading cause of death and disability in Australia. In high income countries, 40% of child deaths are because of traumatic injuries.

Fibrinogen is one of the key clotting factors that needs to be replaced in severe traumatic bleeding. Currently fibrinogen is replaced using cryoprecipitate; a blood product obtained from healthy volunteer donors. This is a precious resource that is stored frozen in the blood bank; it can take a long time to administer and place significant strain on blood banks.

Fibrinogen concentrate (FC) is an alternative product used to assist in blood clotting. It is a product that is derived from blood plasma but stored in powder form and can be reconstituted at the bedside and given quickly.

The study will investigate whether it is quicker to administer FC than cryoprecipitate, which may reduce haemorrhage and improve outcomes.

This study will enrol 68 children from
admitted with severe traumatic bleeding. Time to administration of fibrinogen replacement and the effect of fibrinogen levels will be measured.

The study will address key areas recently highlighted by the National Blood Authority as requiring further research.

Grants Awarded

Emergency Medicine Foundation

National Critical Care and Trauma Response Centre

GC Private Practice Trust Fund

GC Intensive Care Research Trust

Last updated 29 Oct 2020